Contents

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Indication

Listed in Dosage.

Dosage / Direction For Use

Adult : PO Gastric and duodenal ulcers 400 mg bid for 4-8 wk. Benign gastric ulcer 400 mg bid for 8 wk. Eradication of H. pylori associated w/ peptic ulcer disease As triple therapy (ranitidine bismuth citrate 400 mg, clarithromycin 500 mg and amoxicillin 1000 mg): Taken bid for 7 days.

Overdosage

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Administration

Should be taken with food. Swallow whole, do not chew/crush

Contraindication

Moderate to severe renal impairment.

Special Precaution

Exclude malignancy prior to therapy. Renal impairment. Elderly, childn. Pregnancy and lactation.

Adverse Reactions

Blackening of tongue and stools; GI upset, headache, mild anaemia, bradycardia, altered liver enzymes. Rarely, hypersensitivity, confusion, hepatitis, pancreatitis, blood dyscrasias, musculoskeletal disorders, male breast symptoms.

Drug Interaction

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Storage

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Description

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Action

Description: Ranitidine bismuth citrate dissociates in the stomach and releases ranitidine and bismuth. It provides a unique combination of properties including inhibition of secretion of gastric acid by competitive antagonism of the action of histamine at the histamine H2-receptor on the gastric parietal cell, mucosal protective effects and anti-H. pylori action.